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Description: |
viii, 280 pages : illustrations (some color) ; 27 cm |
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Bibliography Note: |
Includes bibliographical references and index. |
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Contents Note: |
Contents: Machine generated contents note: DESIGN, SYNTHESIS, AND MANIPULATION OF GENOMES -- Synthetic DNA Synthesis and Assembly: Putting the Synthetic in Synthetic Biology / Andrew D. Ellington -- Minimal Cells -- Real and Imagined / Hamilton O. Smith -- Genome-Editing Technologies: Principles and Applications / Jia Liu -- MODIFYING THE CENTRAL DOGMA -- Alternative Watson -- Crick Synthetic Genetic Systems / Patricia Moussatche -- At the Interface of Chemical and Biological Synthesis: An Expanded Genetic Code / Peter G. Schultz -- EXPERIMENTAL AND COMPUTATIONAL APPROACHES TO THE DESIGN AND IMPROVEMENT OF BIOLOGICAL PROCESSES -- Cell-Free Synthetic Biology: Engineering Beyond the Cell / Michael C. Jewett -- Building Spatial Synthetic Biology with Compartments, Scaffolds, and Communities / Pamela A. Silver -- Design Automation in Synthetic Biology / Douglas Densmore -- APPLICATIONS TO SMALL MOLECULE PRODUCTION -- The Need for Integrated Approaches in Metabolic Engineering / Jay D. Keasling -- Synthetic Biology of Natural Products / Eriko Takano -- APPLICATIONS TO HIGHER ORGANISMS -- Engineering Gene Circuits for Mammalian Cell -- Based Applications / Martin Fussenegger -- Synthetic Biology in Cell and Organ Transplantation / Sean Stevens -- Synthetic Morphogenesis / Ron Weiss -- Synthetic Botany / Jim Haseloff -- Phage Therapy in the Era of Synthetic Biology / Bolyn Hubby. |
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Summary, Etc. Note: |
Summary: Synthetic biology involves the rational design and construction of biological components and systems - from genetic elements and metabolic pathways to entirely new organisms. Progress in this field has been rapid, and it promises to significantly expand our capabilities in biotechnology, medicine, and agriculture. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the tools and techniques employed by synthetic biologists, how these may be used to develop new drugs, diagnostic approaches, food sources, and clean energy, and what the field of synthetic biology has taught us about natural living systems. The contributors discuss advances in DNA synthesis and assembly, genome editing (e.g., CRSPR-Cas9), and artificial genetic systems. Progress in designing complex genetic switches and circuits, expanding the genetic code, modifying cellular organization, producing proteins using cell-free systems, and developing biodesign automation tools is also covered. The authors also explore ways to produce new organisms and products that have particular attributes - for example, microbial "molecular factories," synthetic organs and tissues, and plants with novel traits. This volume is an essential resource for molecular, cell, and systems biologists who seek to engineer living systems for human benefit. -- from back cover. |
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Name Added Entry: |
Gibson, Daniel G., editor. |