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Description: |
5 pages : tables ; 26 cm. |
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With Note: |
With: Acute and chronic toxicity of rotenone to Daphnia magna (No. 92) : Toxicity of rotenone to developing rainbow trout (No. 93). |
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Bibliography Note: |
Includes bibliographical references (page 5). |
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Summary, Etc. Note: |
Abstract: Information summarized here was developed in three mammalian safety studies of rotenone: chronic oral toxicity in rates, effects on reproduction in rats, and subchronic oral toxicity in dogs. The no-observed-effect-level (NOEL) of rotenone, determined in rats in a 24-month exposure, was 7.5 mg per kilogram of diet. The only difference related to exposure was the lower weight of rats exposed to the higher concentrations (37.5 and 75.0 mg/kg) -- probably because the animals ate less food as a result of taste avoidance. Rotennoe administered continuously to two successive generations of rats at concentrations of 7.5, 37.5, and 75.0 mg/kg in the diet had no effect on the reproductive performance of either sex. The NOEL for toxicity again was 7.5 mg rotenone per kilogram of diet. In beagles that received daily doses of gelatin capsules, animals that received the highest daily dose rate of 10 mg/kg showed the most obvious effects: diarrhea; decreased feed consumption; weight loss during the first 2 months of exposure; mild anemia; abnd consistent decreases in blood glucose, total lipids, and cholesterol. A daily oral does of 2 mg/kg produced only mild signs of these disorders and the low dose of 0.4 mg/kg was considered the NOEL in dogs. Results of studies reported here and in the literature show that even unusually high treatment rates of rotenone do not cause tumors or reproductive problems in mammals. |